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Notably, HGF is implicated in guiding spinal motoneurons to their target muscles in the limbs (Ebens et al., 1996)

In vivo, zinc deficiency does not independently induce ER stress, yet under pharmacologically induced ER stress conditions, zinc-deficient mice exhibit heightened activation of the pro-apoptotic p-eIF2ATF4CHOP axis, accompanied by apoptosis, steatosis and liver injury

ALA Primarily -linolenic acid DHA Docosahexaenoic acid EPA Eicosatetraenoic acid FAT Fatty acid translocase FATP4 Fatty acid transport protein 4 FFAs Free fatty acids GPx Peroxidase HDL High-density lipoprotein LDL Low-density lipoprotein ROS Reactive oxygen species 2-MAGs 2-Monoacylglycerols 5-MTHF 5-Methyltetrahydrofolate TG Triglycerides TrxR Thioredoxin reductase PUFAs Polyunsaturated fatty acids -3 PUFAs Omega-3 polyunsaturated fatty acids VLDLR Low-density lipoprotein receptor VTG Vitellogenin Fe Iron Cr Chromium I Iodine K Potassium Mn Manganese Na Sodium Se Selenium Zn Zinc Glossary References 1

Thus, increased expression of HSPs as a protective stress response may inadvertently prime beta cells for immune destruction, creating a vicious cycle in which cellular stress enhances autoimmunity targeting [93]